Short stature in children with CVID may show genetic and molecular underpinnings, such as variants in PIK3R1, resulting in activated PI3K δ syndrome 2 (APDS2), which may be associated with features of SHORT syndrome characterized by short stature, joint hyperextensibility, ocular depression, Rieger anomaly, and delayed tooth eruption [108,109]. This evidence concerns the gene PIK3R1 and common variable immunodeficiency.