Loss-of-function (LOF) variants in inducible T cell costimulator (ICOS), NFKB1, NFKB2, CTLA-4, LRBA, adenosine deaminase 2 (ADA2), IL-21 receptor (IL21-R), as well as gain-of-function (GOF) variants in PI3KCD associated with immune dysregulation clinical phenotypes, including autoimmune cytopenia, inflammatory skin disease, arthritis, lymphoproliferation, and endocrinopathies, were found in patients with liver disease, supporting the hypothesis of the heterogeneity of organ-specific hepatic disorders in monogenic IEI disorders [67]. This evidence concerns the gene ADA2 and arthritic joint disease.