They included significantly reduced naïve T helper cell and recent thymic emigrant (RTE) cell counts, expanded CD4+CD45RO memory T cell population, along with excessive T CD4+ cell activation corresponding with organ-specific autoimmunity, cytopenia, enteropathy, polyclonal lymphoproliferation, and lymphoid malignancy [34,37,38,39]. The gene discussed is CD4; the disease is Autoimmunity.