JAK3 and common variable immunodeficiency: It has also been assumed that other variants in genes, such as NFKB1 and nucleotide-binding oligomerization domain containing 2 (NOD2) [22], LRBA and Nei-like DNA glycosylase 3 (NEIL3) [23], and CTLA4 and Janus Kinase 3 (JAK3) [24], are related to clinical autoimmune and inflammatory epistasis in CVID.