RBBP8 and breast cancer: At the same time, the expression of genes activated in fibroblasts by knockdown of oncogene EZH2 and genes suppressed in MCF10A cells (breast cancer) by knockdown of RBBP8/CtIP gene, the product of which is a cofactor of BRCA1 in repair of DNA double-strand breaks [33], was decreased in PANC-1 cells with SOX9 knockdown (Table 7, Supplementary Table S12).