NEFL and diabetes mellitus: For the patients having comorbidities, NFL levels were increased in DME compared to DM (FD 5.36 (95%CI: 2.60; 11.04, p < 0.001; adj-p < 0.001) and HC (FD 4.73 (95% CI: 2.48; 9.01, p < 0.001; adj-p < 0.001).