Mutations in UBA5 that encode ubiquitin-like modifier-activating enzyme 5 (UBA5) are the cause of autosomal recessive spinocerebellar ataxia-24 (SCAR24) [30]; moreover, splicing regulator Rbfox2 is required for Purkinje cell function [31]. The gene discussed is RBFOX2; the disease is spinocerebellar ataxia, autosomal recessive 24.