Wilm’s tumor 1 (WT1), associated with Alzheimer’s disease and synaptic plasticity [25], is among the key regulators of downregulated DEGSs, while heat shock response factor 4 (HSF 4), a negative regulator of HSFs [26] and E24F a transcription factor known to be involved in Alzheimer’s disease pathogenesis [27], were identified as a key regulators of upregulated DEGs in male f-ATXN1146Q mice. Here, HSF4 is linked to early-onset autosomal dominant Alzheimer disease.