Specifically, the IFI27+ subpopulation shows upregulation of COL1A1, COL1A2, COL4A1, COL4A2, and COL6A1–COL6A3, whereas BC-AS2 primarily involves COL1A1, COL1A2, COL6A1, and COL6A2. The gene discussed is COL1A2; the disease is breast cancer.