Among HATs, p300 and KAT7 are both overexpressed in BC; the transcriptional coactivator p300 has been shown to be highly correlated with p53 and HIF-1a levels in invasive BCs [143], while KAT7 triggers cancer radioresistance by targeting the PI3K/AKT pathway [144]. The gene discussed is AKT1; the disease is breast cancer.