SUZ12 and breast cancer: DZNep (3-deazaneplanocin A hydrochloride) is a S-adenosylhomocysteine hydrolase (SAAH) inhibitor depleting cellular levels of PRC2 components (EZH2, SUZ12, and EED), suppressing histone methylation, and inducing selective apoptosis in BC cell lines and primary mammary tumors [193,194,195].