SIRT1 and neoplasm: For instance, reintroduction of miR-34a into BC cells has been shown to suppress growth, migration, and invasion by negatively regulating E2F3, CD44, and SIRT1 target genes; in mouse models, liposomal nanoparticles containing miR-34a efficaciously inhibit tumor growth and increases survival, with no evidence of systemic toxicity [292].