Finally, based on the results presented, it is evident that both natural infection and vaccination against SARS-CoV-2 induce a robust maternal immune response based on specific IgA/SIgA, IgM, and IgG immunoglobulins with neutralizing and functional capacity, which may or may not vary depending on the severity or presence of symptoms and the time of diagnosis of COVID-19. Here, CD40LG is linked to COVID-19.