The transition from NGT to T2D was marked by significant changes in eight SNPs, including rs59813747 (FOXD2 gene), rs147467153 (NEGR1 gene), rs145386384 (ZNF106 gene), rs4784964 (SLC38A7 gene), rs59595912 (PTOV1 gene), rs11698919 (PCSK2 gene), and two intergenic variants (rs35566993 and rs7575023) near LINC00557 and LOC105374834. This evidence concerns the gene PCSK2 and type 2 diabetes mellitus.