NLRP3 and nephritis: Previous studies have shown synergistic effects on inflammation and cytotoxicity by activating NLRP3 inflammasomes, inducing necroptosis and autophagic cell death in NRK-52E cells; cinnamaldehyde inhibits NLRP3 inflammasome activation, resulting in reduced albuminuria and reduced glomerulosclerotic kidney inflammation in mice [39,45,46].