ARHGEF12 and chronic obstructive pulmonary disease: miR-196-5p and miR-361-5p were able to promote hyperplasia in endothelial cells by reducing mRNA-ARHGEF12 (miR-196-5p) and increasing the expression levels of mRNA-BCAT1 (miR-361-5p) [61]; they were differentially expressed in blood samples collected from COPD patients compared to controls [61].