CD4 and hypertensive disorder: For example, macrophage infiltration into the renal medulla was heightened in nicotine-induced hypertension [189]; T cell infiltration increased in deoxycorticosterone acetate-induced hypertension [185]; and in angiotensin II-induced hypertension, there was an increased infiltration of total leukocytes, monocytes, macrophages, and T cells (both CD4+ and CD8+) into the kidneys [66].