NLRP3 and myocardial infarction: The sympathetic activation-induced increase in macrophage and neutrophil infiltration into cardiac tissue during myocardial infarction is partially mediated by NLRP3 activation [207], which leads to increased chemokine production, such as MCP-1, via β1 and α1-adrenergic receptor activation in cardiomyocytes (Figure 11).