This approach successfully identified genes with an H3K4me3 peak in normal cells, but not in colorectal cancer cells [Teashirt Zinc Finger Homeobox 3 (TSHZ3) (Supplementary Figure S10), Adhesion G Protein-Coupled Receptor L3 (ADGRL3), Neural Cell Adhesion Molecule 1 (NCAM1), Erythrocyte Membrane Protein Band 4.1 Like 3 (EPB41L3), and OCA2 Melanosomal Transmembrane Protein (OCA2)] (Supplementary Table S5). The gene discussed is OCA2; the disease is colorectal cancer.