A neuroprotective effect for the estrogen regulation of BDNF is consistently seen in individuals with various pathological conditions such as stress, hypertension, ischemic brain injury, and Parkinson’s and Alzheimer’s diseases [29,34,40,41,48,65,71,72,73,74,77,94,105,110,121,124]. The gene discussed is BDNF; the disease is hypertensive disorder.