It has been shown that the interplay between the increased expression of α1-ARs in PBMC and IL-6 secretion may contribute to systemic inflammation and increase IgG production in differentiated B lymphocytes (plasmablasts) that bind to α1A-AR, β2-AR, and muscarinic receptors-2 in patients with CRPS. Here, ADRB2 is linked to complex regional pain syndrome.