Importantly, the activation of GPR120 and the subsequent metabolic effects related to the interaction of the receptor with the Gα protein via activated extracellular signal-regulated kinase (ERK) cascades and increases in the intracellular Ca2+ concentration seem to be potentially beneficial in treating obesity by promoting anti-inflammatory and insulin-sensitizing effects [91,92,93]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.