NFKB1 and colonic neoplasm: The potential role of anthocyanins in the prevention and suppression of CRC proliferation was also reported in various studies through the induction of caspase 3 and 7, the upregulation of p21, and the suppression of TNFα and the NF-kB expression [55,56,57]; interestingly, the anti-proliferative effect exerted by anthocyanin selectively inhibits the growth of colon cancer cells with respect to breast cancer, characterized by low cytotoxic levels [58].