In SW480 cells, ursolic acid treatment decreased the expression of p-PI3K/Akt, p-Erk, p-mTor, COX-2, PGE-2 and NF-kB, arrested CRC cell proliferation, and suppressed migration through the increase in c-PARP, caspase-3 and -9, and cyto-c and the reduction in MMP-9 [157]. The gene discussed is AKT1; the disease is colorectal carcinoma.