MAPK3 and malignant colon neoplasm: For example, after the treatment of different human colon cancer cell lines (HCT-116, HT-29, LoVo, and Caco-2), the block of cell proliferation with the induction of the apoptosis state was observed with (i) the increase in p53 [77], p-Erk1/2, p-JNK1/2, and p-p38MAPK [78] and (ii) the decrease in Erk1/2 and NF-kb [79].