Its anti-cancer properties were elucidated in different cell models of CRC (HCT-15, HCT-116 and SW-480), where it induced a cell cycle arrest at the sub G1 phase [118] with a reduction in NF-kb, p-Akt, mTor, Erk1/2, and PCN expression [119]. Here, NFKB1 is linked to colorectal carcinoma.