This might have been due to the low basal expression of SLC7A11 in both MC38 cells cocultured with adipocytes and the tumor tissue of obese mice (Figure 5D,E,H,K), in contrast to previous reports showing that HFD could exacerbate lung cancer progression by upregulating SLC7A11 [51]. This evidence concerns the gene SLC7A11 and lung carcinoma.