Importantly, this study identified that: (1) treatment of NSCLC cells with exogenous COMP prior to irradiation increased the proliferation, migration and invasion ability of cells compared to irradiated cells alone; (2) overexpression of COMP in NSCLC cells increased the proliferation, migration and invasion ability when irradiated compared to irradiated mock-transduced cells; and (3) the radioprotective effect imparted by both COMP overexpression and exogenous COMP treatment was reduced or prevented with inhibitors of Src or PI3k (downstream intermediates of COMP signaling). Here, COMP is linked to non-small cell lung carcinoma.