The hypothalamus secretes corticotropin-releasing hormone (CRH) causing the production of adrenocorticotropic hormone (ACTH) by the pituitary gland, which stimulates corticosteroid synthesis in the cortex of the adrenal gland [60].The neuroinflammation hypothesis in the pathogenesis of depression assumes that, under psychosocial stressors, proinflammatory cytokines and chemokines are released, which mediate an inflammatory state in the CNS. This evidence concerns the gene CRH and major depressive disorder.