The musculocontractural Ehlers–Danlos syndrome (mcEDS), which is characterized by kyphoscoliosis, muscular hypotonia, skin hyperextensibility and fragility, joint hypermobility, and multiple joint dislocations, is caused by DSE or CHST14 mutations [42,43,44]. The gene discussed is CHST14; the disease is Ehlers-Danlos syndrome, musculocontractural type.