RNPC3 and acute kidney injury: Activatable 19F MRI probes for simultaneous in vivo detection and deep-tissue imaging of reactive oxygen species (ROS; O2•–) and reactive nitrogen species (RNS; ONOO–) in mice with drug-induced acute kidney injury. ROSP-1 and RNSP-2 contain paramagnetic gadolinium which reduces T1- and T2- relaxation of the fluorinated groups. ROS and RNP lead to the release of fluorinated groups from the ROSP-1 or RNSP-2 molecules and therefore the separation from the gadolinium which leads to a strong 19F signal increase.