SARS-CoV-2 is an enveloped virus, characterized by the presence of structural spike proteins, directly involved in viral infection, through their interaction with receptors (i.e., angiotensin converting enzyme 2—ACE2) and coreceptors (i.e., heparan sulphate proteoglycans) exposed on the host cell membrane [1,2,3]. This evidence concerns the gene ACE2 and viral infectious disease.