IFNG and rheumatic disorder: Indeed, previous reports on Ge-132 have documented both immune-activating effects, such as Interferon-γ (IFN-γ) induction and enhanced macrophage and NK cell activity, which result in antitumor effects [31,32], as well as anti-inflammatory effects, including the suppression of rheumatic diseases partly via excessive TNF-α and IL-6 secretion [33].