Further, consistent with findings that AD and VaD often co-exist, our AD TWAS identified genes that were associated with lacunar and ischemic strokes, as well as cerebral small vessel disease in other studies, including SLC39A13 [70], RAPSN [70], MAF1 [71], and MME [72,73]. The gene discussed is SLC39A13; the disease is Alzheimer disease.