ZYX and Alzheimer disease: Although not explicitly identified in Bellenguez et al. (2022) [23], we also identified genes that were associated with AD in other studies, including RIN3 that is implicated in tau-mediated pathology, the MS4A (4A and 6A) locus associated with mast cell activation, TP53INP1 and ZYX that have been linked to myeloid enhancer activity [59], and APOC4, which is located proximal to APOE [60].