Although our WMH TWAS identified 12 genes that were not included in the SNP-based GWAS results mapped to the nearest gene or the gene-based analysis reported in Sargurupremraj et al. (2020) [22], other studies found associations between MAP1LC3B [74], ARMS2 [75,76], and HTRA1 [70] with ischemic stroke, lacunar stroke, and cerebral SVD. The gene discussed is HTRA1; the disease is ischemic stroke.