Furthermore, in correlation with our data, a reversal of the intrinsic apoptotic pathway triggered by doxycycline was observed in the human osteosarcoma-U2OS-derived cell line, along with the recovery and maintenance of mitochondria crista structure, in the presence of a compound that was verified to target the succinate dehydrogenase subunit B (SDHB) protein, a component of complex II of the mitochondrial ETC [63]. Here, SDHB is linked to osteosarcoma.