CXCL10 and systemic sclerosis: Higher CXCL10 is not only associated with a more severe disease prognosis [75] but, remarkably, precedes the development of definite SSc from a preclinical condition of undifferentiated connective tissue disease (UCTD) at risk of SSc, so far referred to as very early diagnosis of systemic sclerosis (VEDOSS) [76].