MAPT and Mental deterioration: The HFHFD changed total tau expression in all the brain areas analyzed and provoked a significant increase in its phosphorylated form, AT8, in both the PFC and HIPPO, suggesting a potential disruption in tau homeostasis and the onset of tau hyperphosphorylation, which could be indicative of early-stage neurodegenerative processes or increased vulnerability to cognitive decline, accordingly to previous evidence [59,60].