TMEM230 and malignant glioma: By comparing U87-MG (cells that recapitulate glial cell tumor and morphological properties of aggressive gliomas of patients with glioblastoma multiforme) control and cells in which levels of TMEM230 were upregulated (Figure 8A,B), we observed that control cells appear with a more “globular” morphology associated with monomer units of actin.