In particular, TMEM230 and RNASET2 expression were absent or very low in all cell types, including immune system cells such as T and B cells, professional antigen-presenting and phagocytic cells (macrophage, dendritic cell, or synovial fibroblast) our analysis suggested that loss of expression of these genes are novel markers that correlate with loss of normal endomembrane activities in trafficking and glycosylation in autoimmunity or aging. The gene discussed is RNASET2; the disease is Autoimmunity.