TMEM230 and rheumatoid arthritis: While we have manipulated the expression of TMEM230 using human-derived cell lines and primary blood vessel-forming endothelial cells, as our conclusions and sequencing analysis are derived from using patient whole tissue (RA, OA), further research will need to be performed in manipulating TMEM230 expression using patient-derived cells to generate 3D organoids and co-cultures assays that we have previously established to validate our expression profiles and conclusions [13].