HES1 knockdown reduces GLUT1 levels, aerobic glycolysis, and CRC proliferation, while IMP2 is required for HES1-mediated stabilization of m6A-modified GLUT1 mRNA, underscoring the importance of the HES1-IMP2 axis in CRC progression [95]. The gene discussed is IGF2BP2; the disease is colorectal carcinoma.