Here, we will cover the key findings and effectors of IMP2 action in colorectal cancer, breast cancer, leukemia and lymphoma, hepatocellular carcinoma, lung adenocarcinoma, ovarian malignancies, endometrial cancer, oral cancer, renal cell carcinoma, thyroid cancer, and glioblastoma. The gene discussed is IGF2BP2; the disease is hepatocellular carcinoma.