TGFB1 and cancer: For CC and other types of HPV+ cancer, EVs secreted by tumor cells may contain different biomolecules, including the oncoproteins E6* and E7* and proteins that regulate the immune response, such as TGF-β, FasL, OX40, and OX40L [37]; microRNAs [38,39]; lncRNAs [40]; circRNAs [41]; mRNAs [42]; E1*, L1*, E6*, and E7* DNA [43]; and purine metabolites that promote immune escape [44].