IGF1 and pituitary dwarfism: Patient P3, carrying the novel c.557T>G p.(Leu186Arg) variant, was diagnosed in the neonatal period with symptoms including constipation, prolonged neonatal jaundice, pituitary dwarfism, anterior pituitary hypoplasia, and low levels of IGF1, TSH, FT4, GH, and PRL.