In comparison with normal AML12 cells:Glo1 in Huh-7 ↑ (mRNA, protein and activity);Glo1 in HepG2 ↑ (only mRNA);Effects of Glo1 inhibition in Huh-7 cells (by 1–20 mM ethyl pyruvate or 1–10 μM BrBzGSHCp2):proliferation ↓, migration ↓,colony formation ↓;PDGFR-β ↓, VEGFR2 ↓, VEGF ↓, pERK/ERK ↓, NF-κB ↓;Nrf2 ↑.Effects of 2.5–10 μM sorafenib (a multi-tyrosine kinase inhibitor approved for the therapy of advanced HCC):Glo1 ↑, MGO ↑. This evidence concerns the gene EIF2AK3 and hepatocellular carcinoma.