BID and acute lymphoblastic leukemia: In the case of HIV infections, the pLtBid(INS)2R DNA vector selectively triggered apoptosis in infected cells by linking tBid expression to the presence of viral proteins Tat and Rev. Similarly, a CRISPRa system combined with a CD3-retargeted tBid-encoding vector effectively and selectively targeted latent HIV-infected T ALL cells, inducing their apoptosis.