In summary, APOL6, ARF6, CCDC6, DSG2, EFNB2, EPS8, LAPTM4A, MYEOV, PPFIBP1, RAB27B, RAB9A, RHOD, SAV1, STAT1, TNFSF10, and TSPYL2 are noteworthy as prognostic indicators of PAAD. Here, DSG2 is linked to pancreatic adenocarcinoma.