As shown in Figure 12 and Table 2, the endothelial markers’ expression, namely CD31 and VE-cadherin, and the mesenchymal markers’ expression, namely vimentin and N-cadherin, were lower and higher, respectively, in HUVECs treated with the EVs isolated from SSc patients than those found in HUVECs treated with EVs isolated from HCs. The gene discussed is CDH5; the disease is systemic sclerosis.