MMP2 and glioblastoma: Therefore, our objectives were as follows: (1) evaluation of the cytotoxic properties of BV against selected glioblastoma multiforme lines, (2) chromatographic separation of BV into three fractions which will each contain one of the main natural components of BV: apamin, phospholipase A2, and melittin, (3) assessment of the cytotoxic properties of the obtained fractions, (4) evaluation of the obtained fractions’ effect on the activity of MMP-2 and MMP-9 secreted into the culture medium.