In ovarian cancer cell lines SKOV-3 and OVCAR-3, Ex-4 induces apoptosis by modulating NF-κB downstream targets, including matrix metalloproteinase-9 (MMP-9), intercellular adhesion molecule-1(ICAM-1), BAX, Bcl-2, and cyclin D [68]. The gene discussed is ICAM1; the disease is ovarian cancer.