SHAP analysis indicated that age over 53 years, BMI over 25, TC over 5.6 mmol /L (100.8 mg/dl), ApoB value over 0.9 g/L, TG over 1.4 mmol /L (124.2 mg/dl), hypertension, TP over 81 g/L, HDL_C less than 1.2 mmol /L (46.4 mg/dl), WBC over 6.2 × 109 /L may be the risk factors for pre-diabetes. The gene discussed is APOB; the disease is diabetes mellitus.