Flow cytometry analysis revealed a significant increase in the infiltration of neutrophils, NK cells, effector T cells, and effector B cells in NEXN knockout mouse models (p < 0.05) (Fig. 10A); while in NEXN overexpression mouse models, the infiltration of these immune cells significantly decreased (Fig. 10B), suggesting that NEXN may influence the development of AAA by regulating immune cell infiltration. Here, NEXN is linked to triple-A syndrome.