NEXN and triple-A syndrome: CCK-8 assay results showed that overexpression of NEXN significantly inhibited the proliferation ability of HUVEC and HAoSMC cells (p < 0.05) (Fig. 8A), while knockout of NEXN led to a significant increase in cell proliferation capability (p < 0.05) (Fig. 8B), indicating that NEXN plays a role in inhibiting cell proliferation related to AAA.