High doses of CA-4 (e.g. 30–100 mg/kg) in mouse tumors cause selective vascular death within hours after treatment (Dark et al, 1997); this also translates into significant reduction of tumor perfusion within 24 h as measured by dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in rat and human tumors, indicative of anti-vascular effects (Galbraith et al, 2003). This evidence concerns the gene CA4 and neoplasm.