VEGFA and neoplasm: Quantitative analysis of the collagen matrix surrounding PNET tumors demonstrated that CA-4 or eribulin maintained tumor encapsulation whereas DC101 resulted in rupture of the tumor collagen boundary (Fig. 4E), a first step in the process of local tumor invasion driven by hypoxic pressure following the loss of blood vessels under chronic VEGF inhibition (Paez-Ribes et al, 2009).