Recently, we found that angiogenic tumor pericytes exist in a synthetic, highly proliferative state but can be switched to a more mature (or contractile) phenotype by activating intrinsic Rho-associated coiled-coil forming kinase (ROCK1, RhoA kinase (Johansson-Percival et al, 2015; Li et al, 2024). Here, ROCK1 is linked to neoplasm.