TRMT10A and central nervous system cancer: Immunohistochemistry staining revealed that TRMT10A, mainly as cytoplasmic staining was found to be highly expressed in non-neoplastic brain tissues, while no strong immunoreactivity was detected in glioma tissues of low-grade (LGG, WHO I-II) and high-grade (HGG, WHO III-IV) (Fig. 1B).