When the G9 position of tRNA-ArgCCT is mutated, downregulation of TRMT10A expression does not alter the level of tRF-22, suggesting that in glioma cells, downregulated TRMT10A increases tRF-22 expression by reducing the m1G9 modification of tRNA-ArgCCT, thereby decreasing tRNA stability. The gene discussed is TRMT10A; the disease is central nervous system cancer.