Other JAK2 mutations associated with myeloid neoplasms and acute lymphoblastic leukemia (ALL) include R683G, R683S, and R683T, which drive malignant transformation by continuously activating downstream signaling cascades, resulting in increased proliferation of hematopoietic stem- and progenitor cells [90–93]. The gene discussed is JAK2; the disease is acute lymphoblastic leukemia.