TYK2 fusions such as MYB::TYK2, NPM1::TYK2, NFkB2::TYK2, and PABPC4::TYK2 are found in lymphomas and ALL leading to constitutive TYK2 signaling and contributing to malignant transformation [111, 123]. The gene discussed is TYK2; the disease is acute lymphoblastic leukemia.