To elucidate the mechanism underlying this difference, we categorized CRC cell lines into three distinct groups according to their respective dependency score; KAT2A dependent (marked in blue, dependency score < −0.4), KAT2A intermediate (marked in black, dependency score between −0.4 and −0.1), and KAT2A independent (marked in green, dependency score > −0.1). This evidence concerns the gene KAT2A and colorectal carcinoma.