Instead, especially MSS CRCs with differentiation-associated transcriptional profiles, characterized by high expression of enterocyte-specific marker genes and the expression of keratin genes KRT20 and KRT23, depend on KAT2A. CRC is characterized by high heterogeneity and was originally classified into four histological grades based on tumor differentiation, with less-differentiated tumors associated with the worst prognosis [55] and higher frequency of MSI-H [56], a clinical feature that we identified as mutually exclusive with KAT2A dependency. Here, KAT2A is linked to colorectal carcinoma.