HPGD and colorectal carcinoma: Furthermore, when examining differentially expressed genes at the individual gene expression level between KAT2A independent and dependent CRC cells, we observed significantly higher expression of enterocyte-specific marker genes [34] – specifically, EDN1, HPGD, IRF7, KRT23, and DDX60 as well as pan-differentiation marker KRT20 in the KAT2A dependent group (Fig. 2d).