Observational studies have shown that some inflammatory markers such as IL-6 and TNF-α are elevated in long sleepers28, and the production of inflammatory cytokines (such as IL-6, TNF-α) will recruit monocytes and other inflammatory cells to local liver tissues, leading to further aggravation of the liver’s inflammatory response29, and also affecting the insulin signaling pathway, leading to the occurrence of insulin resistance30, aggravating the deposition and degeneration of fat in the liver, and leading to the occurrence and aggravation of fatty liver. This evidence concerns the gene INS and fatty liver disease.