Reduced sleep quality leads to the activation of NF-κB and MCP-120, promotes the production of inflammatory cytokines (such as IL-6, IL-8, TNF-α)21, recruits monocytes and other inflammatory cells to local liver tissues, and these inflammatory factors further aggravate the inflammatory response of the liver, and also affect the insulin signaling pathway, leading to the occurrence of insulin resistance, aggravating the deposition and degeneration of fat in the liver, and leading to the occurrence and aggravation of fatty liver. This evidence concerns the gene NFKB1 and fatty liver disease.