The current investigation used samples from POPVAC A to measure plasma markers of gut microbial translocation (intestinal fatty acid-binding protein 2 [I-FABP2], lipopolysaccharide-binding protein [LBP], anti-endotoxin core antibodies [EndoCab], soluble CD14 [sCD14]), and faecal markers of gut inflammation (lipocalin-2 [fLcn-2], occult blood [FOB], and calprotectin [fCAL]), evaluating their associations with baseline helminth infection, praziquantel treatment, and vaccine responses. Here, LCN2 is linked to helminthiasis.