In a notable study led by Belmonte, the authors demonstrated a targeted partial reprogramming approach using adeno-associated viruses to deliver OSK under the control of the cyclin-dependent kinase inhibitor 2a (Cdkn2a) promoter, which allowing for specific and partial reprogramming of aged and stressed cells in a mouse model of Hutchinson-Gilford progeria syndrome (HGPS) (Sahu et al. 2024). This evidence concerns the gene CDKN2A and Hutchinson-Gilford progeria syndrome.