In a proof-of-concept study led by Pereira, the authors reported the successful reprogramming of 36 cancer cell lines derived from human/mouse hematological and solid tumors into professional antigen-presenting cells (tumor cell-derived APCs) via the enforced expression of the transcription factors PU.1, IRF8, and BATF3 (Zimmermannova et al. 2023). Here, SPI1 is linked to cancer.