On the other hand, an increase in the expression levels of DNMT3A and DNMT3B was also observed in cells exposed to treatments with β-OHB, which catalyze de novo DNA methylation and their overexpression is related to several types of cancer and primary tumors [68, 69], among them they are involved in the oncogenesis and progression of breast cancer [69]. This evidence concerns the gene DNMT3B and breast carcinoma.