As described in Fig. 4, although it was not statistically significant, we observed a slightly higher median value of cells density within tumor invasive margin of DD subgroup (1758 for CD3 + cells and 903 for CD8 + cells, respectively) compared to DI subgroup (1463 for CD3 + cells and 650 for CD8 + cells) that was relatively similar with the M subgroup (1114 for CD3 + cells and 508 for CD8 + cells). This evidence concerns the gene CD8A and neoplasm.