Overall, 10 independently significant loci have been identified as shared between cholelithiasis and GERD by both MTAG and CPASSOC, namely, rs146812426, rs4299376, rs6733452, rs7596134, rs10935762, rs12633863, rs4681515, rs3922717, rs802036, and rs9297994, which mapped to 9 genes, including PLEKHH2, ABCG8, DYNC2LI1, ABCG5, TM4SF4, LOC100270746, CROT, UBXN2B, and CYP7A1 (Table 3). This evidence concerns the gene TM4SF4 and cholelithiasis.