Prior research has reported the negative effect of CBY1 and SUN2 genes on tumorigenesis [69–71], which implied a potential role of them in the pathogenesis of gallstone disease and GERD, given that these 2 diseases are risk factors for gallbladder and esophageal cancer, respectively [72, 73]. The gene discussed is CBY1; the disease is gastroesophageal reflux disease.