Overall, 10 independently significant loci have been identified as shared between cholelithiasis and GERD by both MTAG and CPASSOC, namely, rs146812426, rs4299376, rs6733452, rs7596134, rs10935762, rs12633863, rs4681515, rs3922717, rs802036, and rs9297994, which mapped to 9 genes, including PLEKHH2, ABCG8, DYNC2LI1, ABCG5, TM4SF4, LOC100270746, CROT, UBXN2B, and CYP7A1 (Table 3). The gene discussed is ABCG8; the disease is gastroesophageal reflux disease.