AKT1 and autoimmune disease: There are also reports showing that Akt isoforms differentially regulate Th1/Th17 responses during experimental autoimmune encephalomyelitis disease progression and Th1‐regulatory T cell (Treg) generation in autoimmune diseases.21 22 Pharmacological inhibition of Akt1 and Akt2 has been shown to enhance the central memory phenotype of CD8+ T cells while preventing terminal differentiation.23