To gain a deeper understanding of the mechanisms underlying how Akt2 signaling enables CTLs to overcome the immunosuppressive HCC TME, we conducted an analysis of global gene expression levels in control CTLs, Akt1-OE CTLs, and Akt2-OE CTLs, both at rest and after re-stimulation, using RNA-seq analysis.33 This evidence concerns the gene AKT2 and hepatocellular carcinoma.